The association between serum albumin and HDL and total cholesterol.
Figure 1: Relation between serum Albumin with Cholesterol of NS . Marsh JB, Sparks CE () Hepatic secretion of lipoproteins in the rat. Albumin, total cholesterol and iron are 'routine measurements' in LASA. min- max] of serum albumin, total cholesterol, LDL-, HDL-cholesterol and . Clarifying the direct relation between total cholesterol levels and death. Lipoprotein(a) levels in relation to albumin concentration in childhood Delta% of apoB and LDL cholesterol (LDL-C), but not with the Delta% variation of Lp(a).
The precise cause of the edema and its persistence is uncertain. A complex interplay of various physiologic factors, such as the following, probably contribute : Decreased oncotic pressure, increased activity of aldosterone and vasopressin, diminished atrial natriuretic hormone and activities of various cytokines and physical factors within the vasa recti.
INS is accompanied by disordered lipid metabolism. The traditional explanation for hyperlipidemia in INS was the increased synthesis of lipoproteins that accompany increased hepatic albumin synthesis due to hypoalbuminemia. However, serum cholesterol levels have been shown to be independent of albumin synthesis rates.
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Decreased plasma oncotic pressure may play a role in increased hepatic lipoprotein synthesis. Also contributing to the dyslipidemia of INS are abnormalities in regulatory enzymes, such as lecithin-cholesterol acyltransferase, lipoprotein lipase, and cholesterol ester transfer protein [12,13].
The mechanism for its occurrence is complex and involves a combination of reduced clearance of lipoproteins from the circulations  and increased hepatic synthesis of lipoproteins [15,16,].
Most investigators have found a negative correlation between serum albumin concentration and serum cholesterol levels [22,23]. Some degree of correlation between lipids and serum albumin as suggested by Thomas et al. Hyperlipidemia usually observed during the active phase of the disease and disappears with the resolution of proteinuria.
But also high serum total cholesterol levels predicts higher CHD mortality and morbidity.
Lipoprotein(a) levels in relation to albumin concentration in childhood nephrotic syndrome.
Measurements Both serum albumin and total cholesterol levels were determined directly. This blood was analyzed in two laboratories in the B-cycle: VUmc Serum albumin concentration was determined by fotometry using a bromocresol-purper method.
This method is more sensitive for immunoglobulines than methods used in other labs esp. Weezelanden Serum albumin concentration was determined by BCG bromocresol green method.
Albumin and cholesterol
See further in this document "Syntax conversion albumin". This method is similar to the kinetic Jaffe method. This is especially of importance when looking at change in serum levels between B and C not recommended because of different methods and laboratories!
Another important point is that the VU University Medical Center have lower serum levels in general as compared to the other labs, this is the case for both serum albumin and serum total cholesterol.